The inhabitants of Earth are mostly microbes, and their activities are central to human welfare. Microbes can cause disease, but a properly functioning microbiome is essential for health. Microbes spoil food, but drive many forms of food production. Microbes mediate organismic decay, but catalyze numerous geochemical processes essential for life on Earth.

Research in the Penn Microbiology Department focuses on infectious agents that threaten global health, with an emphasis on understanding molecular mechanisms and developing key new methods. Areas of focus include pathogenic bacteria of the airway and gut, HIV/AIDS, insect- and rodent-borne viruses, herpes viruses, papillomaviruses, emerging infectious diseases and the human microbiome. On the host side, faculty study many areas of immunology related to infection, including innate and adaptive immunity, tumor immunology and vaccine development.


Thanks @LabRandolph for an awesome visit and amazing @PennMicro seminar today — incredible images of gut lymphatics and how they are disrupted during IBD. Was wonderul to learn more on intestinal macrophage biology and their trafficking during health and disease!

“Imagine a world where an infant is born or comes into the clinic very early in life and can receive vaccines that have antigens not just for the flu but a multitude of different pathogens. Wouldn’t that be something?”
https://t.co/sHZ3SpLs8x via @PennMedicine

Víctor Vázquez, #PennSUIP & @uprrp alumnus & current PhD student @PennMedicine, shares Why #PennSUIP? “#PennSUIP is a prog that truly cares abt #mentoring. I found amazing mentors that I know will be there for me throughout my devt as a scientist.” Photo: Office Univ. Comm. @Penn

Maternal antibodies are awesome but they can inhibit de novo immune responses elicited by vaccines. In this paper, we identified a nucleic acid-based vaccine that can slip under the radar of maternal antibodies and elicit good antibody responses.

#2TopTweet2019: Uncovering a world of new viruses: @BushmanLab & Ron Collman lab identified a previously unknown viral family and it turns out to be the 2nd-most common DNA virus in human lung and mouth specimens! @PennMicro, @CellPress, @NIH, @NSF, https://t.co/DHItjNqt91

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Prokaryotic Seminar
Monday, 1/20/20, 4pm, 209 Johnson Pavilion
No Seminar

Virology Seminar
Monday, 1/21/20, 4pm, 209 Johnson Pavilion
Lindsay Festa, PhD  (Jordan-Sciutto Lab) :: Colby Maldini (Riley Lab)

Microbiology Seminar
Wednesday, 1/15/20, 12pm, CRB Auditorium
Philip Kranzusch, PhD :: Harvard Med Sch
cGAS-like enzymes in immunity and host-microbiome signaling