The inhabitants of Earth are mostly microbes, and their activities are central to human welfare. Microbes can cause disease, but a properly functioning microbiome is essential for health. Microbes spoil food, but drive many forms of food production. Microbes mediate organismic decay, but catalyze numerous geochemical processes essential for life on Earth.

Research in the Penn Microbiology Department focuses on infectious agents that threaten global health, with an emphasis on understanding molecular mechanisms and developing key new methods. Areas of focus include pathogenic bacteria of the airway and gut, HIV/AIDS, insect- and rodent-borne viruses, herpes viruses, papillomaviruses, emerging infectious diseases and the human microbiome. On the host side, faculty study many areas of immunology related to infection, including innate and adaptive immunity, tumor immunology and vaccine development.


We developed a new multivalent mRNA vaccine against all known influenza virus subtypes. Our study describing the vaccine was just published in @ScienceMagazine. 1/n

Promising universal flu vaccine could protect against 20 strains https://www.newscientist.com/article/2348576-promising-universal-flu-vaccine-could-protect-against-20-strains/?utm_term=Autofeed&utm_campaign=echobox&utm_medium=social&utm_source=Twitter#Echobox=1669318402

Congrats to Smith, Zackular and coworkers on their new findings on C. difficile in the human gut—"Enterococci enhance Clostridioides difficile pathogenesis" just out in Nature!

Lecture tomorrow on Monkeypox and beyond! The talk will be targeted to all interested listeners, not just specialists. Stu Isaacs is a great speaker—please attend!

Hi everyone! It's been a while since we last posted but we're back with another member highlight! Sunny Shin (@SunnyShinLab /she/her) is one of our faculty members in TAA and is the director of the CAMB MVP subprogram!

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Prokaryotic Seminar
Monday, 11/28/22, 4pm, 209 Johnson Pavilion
Neha Nataraj, Brodsky and Shin Labs
“RIPK1 is dispensable for apoptosis in human macrophages in response to Yersinia blockade of immune signaling”

Virology Seminar
Tuesday, 11/29/22, 12pm, 209 Johnson Pavilion
Joangela Nouel, White Lab ::  Jae Seung Lee, Cherry Lab

Microbiology Seminar
Wednesday, 11/30/22, 12pm, CRB Aud or: https://primetime.bluejeans.com/a2m/live-event/xqbzwhrb
Andrés Finzi, PhD ::  CHUM Research Centre
“Modulating HIV-1 Env conformation to eliminate infected cells”

Special Seminar, sponsored by CCEP: Penn Center for Research on Coronavirus and Other Emerging Pathogens
Thursday, 10/27/22, 4pm in Jordan Law Auditorium – Link to recording of talk
Stuart Isaacs, MD :: Dept. Medicine, Univ Pennsylvania
“The return of poxviruses as a cause of widespread human disease – from smallpox to monkeypox”

Symposium III: Understanding COVID-19 and Addressing Disparities in Care, 1-5pm, Nov 2, 2021 (All Talks) (sponsored by the Penn Center for Research on Coronavirus and Other Emerging Pathogens)

Symposium II: The Developing COVID-19 Epidemic, July 8, 2020 (All Talks) (sponsored by the Penn Center for Research on Coronavirus and Other Emerging Pathogens)

Symposium I: The Coronavirus Outbreak, April 3, 2020 (All Talks) (sponsored by the Penn Center for Research on Coronavirus and Other Emerging Pathogens)