BBCBgrad group | PSOM at the University of Pennsylvania

Faculty

A strength of the BBCB program is its broad combination of faculty interests and disciplines. 59 Faculty members are drawn from many departments in the Perelman School of Medicine, 5a from other schools in the University, and from affiliated local research institutes. 82 The faculty are unified by research that is quantitative, mechanistic, molecular; That is founded on principles of chemistry 74 and physics; By the development of advanced biophysical, biochemical and chemical methods and instrumentation; 7b By the training of graduate students in these areas of research and that more broadly aligns with the mission of BBCB. 9

33 27 45 e 18 4b 3c 3c 3c 3c 3c 3c 3c 3b 3b 3c 3b 3c 3c 3c 3c 2b 3c 3c 3b 2b 3c 3c 2b 3b 3b c d

5e FACULTY ALPHABETICALLY: 20

30 14 7d 8 14 7e a , 14 70 8 14 7c 8 14 67 8 14 a0 8 14 63 8 9

FACULTY BY RESEARCH INTEREST:

Control of Gene Expression, RNA Biology, Cellular Programming
5d Baur 5a Berger 46 Bernstein 6c Blanco, A. 56 Blanco, K. 45 Bomba-Warczak 5c Bonasio 57 Brass 5a Busino 5e Cherry 5e Conn 59 Dreyfuss 49 Frangos 57 Gardini 57 Greenberg 59 Gupta 68 Jordan-Sciutto 5e Kohli 60 Lakadamyali 5b Lazar 57 Lewis 36 Li 46 Lin 42 Little 57 Liu 37 Lorenzo 59 Lynch 62 Marmorstein 6c Modzelewski 5d Murakami 5f Murray 4f Raj 63 Roulis 5f Shi 5b Shorter 3f Song, Y 3e Song, H 62 Stevens 3e Taabazuing 46 Tian 39 Tolbert 5d Trauner 41 Tvardovskiy 5a Van Duyne 40 Wan 65 Wang 5a Wellen 5e Zaret 69 Zhou, Z.

Cell Signaling, Intracellular Trafficking
59 Berger 57 Black 43 Bomba-Warczak 49 Brady 57 Brass 58 Busino 5b Chanaday 5b Conn 4b Dominguez 58 Dreyfuss 49 Goulian 56 Greenberg 44 Holzbaur 5c Kohli 5d Lakadamyali 4c Lampson 5d Lee, E. 35 Lorenzo 58 Lynch 54 Marks 65 Pohlschroder 5a Prosser 57 Salzberg 5d Shi 3d Song, H 3d Song, Y 3c Taabazuing 40 Wan 5 64 Zhou, Z.
4 10

Chemical Biology, Protein Engineering, Structural Biology
4d Baumgart 57 Black 63 Boesze-Battaglia 44 Bomba-Warczak 3d Bowman 49 Brady 38 Burslem 51 Chenoweth 64 de la Fuente 42 Dominguez 44 Frangos 57 Goldman 57 Greenberg 54 Gupta 5b Kohli 58 Ma 5f Marmorstein 4e Matthews 64 Moiseenkova-Bell 5b Murakami 55 Ostap 3b Patel 57 Penning 52 Petersson 50 Rhoades 54 Rubin 4b Saven 5a Sellmyer 55 Sharp 3b Sgourakis 59 Shorter 65 Skordalakes 3c Song, H 37 Tolbert 5b Trauner 57 Van Duyne 5d Zhou, Lijun e

Bioenergetics, Metabolism, Membranes
5a Bartman 4d Baumgart 5a Baur 57 Goldman 59 Lazar 35 Lorenzo 55 Ostap 57 Penning 4f Rhoades 63 Pohlschroder 58 Salzberg 54 Sharp 4a Shen 3d Song, Y 5d Weljie 58 Wellen 5e White 5a Witschey 67 Zhou, Lijun

Biophysical Instrumentation, Techniques, Nanotechnology, Microscopies and Imaging
58 Black 54 Busch 5b Chanaday 38 Chang 5a Cormode 5e Farwell 56 Greenberg 5d Lakadamyali 4c Lampson 2e Mir 55 Ostap 3b Patel 56 Reddy 50 Rhoades 5a Sellmyer 3b Sgourakis 4a Shen 43 Timperman 37 Tolbert 52 Tsourkas 3f Tvardovskiy 56 Wehrli 56 Weisel 59 Witschey 61 Zhou, Lijun

Molecular Immunology
5a Bartman 53 Escolano 43 Frangos 57 Lynch 58 Ma 61 Roulis 5b Sellmyer 3a Sgourakis 3d Taabazuing 43 Tian 5 5 a

2b LIST OF ALL FACULTY
9 18 1 1 9 18 1 52 6b Caroline Bartman, Ph.D, Metabolic flux, metabolomics, isotope tracing, cancer, immunology
45 65 Tobias Baumgart, Ph.D, Biomembrane function: thermodynamics, dynamics and mechanics
56 5c Joseph A. Baur, Ph.D Molecular mechanisms of aging and caloric restriction
52 80 Shelley L. Berger, Ph.D, Role of adaptors in regulation of transcriptional activation in yeast and humans
83 Kara Bernstein, Ph.D DNA damage, repair and tumorigenesis
57 93 Ben E. Black, Ph.D, Chromosome segregation; chromatin structure; epigenetic centromere specification; hydrogen/deuterium exchange
5f 64 Andres Blanco, Ph.D, Epigenetics in normal and pathological (eg. cancerous) cells
6e Kahlilia Blanco, Ph.D , 42 epigenetics, mitochondrial properties, stroke pathophysiology
53 78 Kathleen Boesze-Battagalia, Ph.D, Degradative processes, phagocytosis and autophagy, cell homeostasis
34 6f Ewa Bomba-Warczak, Ph.D, Lifelong maintenance of mitochondrial networks in long-lived cells.
4c 5e Roberto Bonasio, Ph.D, Noncoding RNAs in chromatin biology and epigenetics.
8f Greg Bowman, Ph.D, Protein folding, structure and dynamics, simulations
52 65 Donita C. Brady, Ph.D, Cancer biology, signal transduction, and metal homeostasis.
55 6b Lawrence Brass, MD, Ph.D, Molecular basis for intracellular signaling in vascular biology
2f 6f George Burslem, Ph.D Protein Engineering, Chemical Biology, Post-translational Modifications
55 53 Theresa Busch, Ph.D, Photodynamic therapy, tumor microenvironment
52 59 Luca Busino, Ph.D, Mechanisms of protein ubiquitylation and degradation
9 18 6f Natali Chanaday 30 Communication in neurons, Neurotransmitters
6c Yi-Wei Chang Cyro-EM tomogrophy of cells
47 78 David Chenoweth, Ph.D, Development and application of synthetic methods for creating molecules that mimic 23 or interact with biomolecules.
56 5f Sara Cherry, Ph.D, Genetic and mechanistic studies of viral-host interactions
77 Crystal Conn, Ph.D 65 Cancer Biology, Adaptive Stress Responses, mRNA Translation, Drug targeting, Protein Homeostasis
52 6e David Cormode, Ph.D, Medical imaging, nanoparticles, contrast agents, cardiovascular disease
1 2e

1 4b 85 Cesar de la Fuente, Ph.D, Machine Biology, Synthetic Biology, Computational Biology, Microbiology, Bioengineering.
57 51 Roberto Dominguez, Ph.D, Actin cytoskeleton, structural biology
1 18 6e Amelia Escolano, Ph.D, 4a Immunology, antibody affinity maturation, rational design of vaccines
1 18 57 68 Michael Farwell, MD, Developing new imaging tools, oncological applications of imaging
3c 5e Andrew Santiago Frangos, Ph.D, Mechanisms and applications of immune systems
1 18 1 4d 8d Alessandro Gardini, Ph.D, Understanding the role of enhancers and noncoding RNAs in transcriptional regulation in mammals.
1 42 5c Mark Goulian, Ph.D, Two-component signaling, bacterial regulatory circuits
4c 81 Roger Greenberg, MD, Ph.D, Basic DNA repair mechanisms that impact cancer etiology and therapy
4f 7b Kushol Gupta, Ph.D, Structural biology of large macromolecular assemblies that regulate genetic information; 33 X-ray crystallography; small-angle scattering.
20 1 47 75 Erika Holzbaur, Ph.D, Molecular motor-driven dynamics of organelles along the cellular cytoskeleton
1 18 1 1 18 1 4c 65 Paul A. Janmey, Ph.D, Cytoskeleton, biopolymer mechanics, phosphoinositides
1 57 97 Kelly Jordan-Sciutto, Ph.D, Integrated Stress Response, Molecular mechanisms underlying neuronal loss in neurodegenerative disorders.
1 29 1 4e 9 6e Rahul M. Kohli, MD, Ph.D, Enzymatic basis for heterogeneity in the immune system and pathogens; 3b enzyme mechanisms, chemical biology, protein evolution
1 29 1 52 7b Melike Lakadamyali, Ph.D We study cytoskeleton and nuclear organization with super-resolution microscopy.
44 75 Michael Lampson, Ph.D, Chromosome segregation in mitosis and meiosis, biosensors for mitotic kinase
36 6e Mitchell Lazar, MD, Ph.D, Nuclear receptors and the transcriptional regulation of metabolism
55 52 Edward B. Lee, MD, Ph.D, Neuropathology Alzheimer's, ALS disease
55 7a Mitchell Lewis, D.Phil. , Gene regulation; protein crystallography; structural basis of recognition
31 57 Carman Man-chung Li, Ph.D Hereditary cancers, Germline heterozygosity
40 60 Lan Lin, Ph.D RNA modifications (a.k.a "epitranscriptomics") in human diseases
39 80 Shawn C. Little, Ph.D, Transcription bursting dynamics; single molecule measurements; cell fate specification
52 6f Kathy Fange Liu, Ph.D, The nature and mechanism of mRNA modification and its role in disease
a0 Damaris Lorenzo, Ph.D Molecular mechanisms of diseases of the nervous system, metabolic disorders
57 66 Kristen W. Lynch, Ph.D, Mechanism and consequences of regulated alternative splicing
1 29 54 59 Leyuan Ma, Ph.D, Protein Engineering, Chemical Biology, Immunotherapies
54 7a Michael S. Marks, Ph.D, Molecular mechanisms of intracellular protein transport and organelle biogenesis
54 9e Ronen Marmorstein, Ph.D, Epigenetics, Protein acetylation, MAPK signaling, Metabolism, Structural Biology, Enzymology, Inhibitor Development
8d Megan Matthews, Ph.D Chemical biology and enzymology.
82 Mustafa Mir, Ph.D Imaging, single molecule dynamics of gene expression
5f 5e Andrew Modzelewski, Ph.D , Retrotransposon activity, Endogenous Retroviruses
1 52 78 Vera Moiseenkova-Bell, Ph.D, Cryo-EM, structure and function of transient receptor potential channels.
1 52 5d Kenji Murakami, Ph.D, Transcription initiation and regulation in eukaryote.
1 49 4c Maureen E. Murphy, Ph.D Tumor suppressor proteins, Cancer
56 76 John I. Murray, Ph.D., 64 Embryonic transcriptional regulation; fate specification; cell lineages; C. elegans; microscopy
1 22 1 20 1 4d 6d E. Michael Ostap, Ph.D, Biochemistry of contractile proteins, biophysics of cell motility, and 2f characterization of unconventional myosins
1 29 1 4b 4b Amish Patel, Ph.D Predictive computational framework for 47 characterizing biomolecular hydration, interactions and assemblies
55 96 Trevor M. Penning, Ph.D, Structure-function of aldo-keto reductases; role in steroid hormone action and chemical carcinogenesis
47 71 E. James Petersson, Ph.D., Semi-synthesis of labeled proteins to probe and control conformation
76 Mecky Pohlschroder 37 Prokaryotic Cell Surface Biogenesis and Function.
51 79 Benjamin L. Prosser, Ph.D., Mechano-signaling in the heart, Therapies for neurodevelopmental disorders.
1 29 29 1 51 59 Arjun Raj, Ph.D, Systems biology; developmental biology; non-coding RNA
51 86 Ravinder Reddy, Ph.D, Sodium and oxygen-17 MR methods; multiple quantum and polarization transfer MR techniques
48 76 Elizabeth Rhoades, PhD, Functional and dysfunctional mechanisms of intrinsically disordered proteins
59 97 Manolis Roulis, PhD , Function and architecture of the mesenchymal microenvironment in tissue homeostasis, immunopathology and cancer
54 8f Harvey Rubin, MD, Ph.D, Pathogenesis of dormancy in mycobacterium tuberculosis; biomolecular computation, and enzymology
1 29 1 55 7a Brian M. Salzberg, Ph.D, Multiple-site optical recording; excitation-secretion coupling; neural networks
57 69 Jeffery G. Saven, Ph.D, Theory, simulation and design of proteins and folding molecules
52 61 Mark Sellmyer, MD, Ph.D Molecular Imaging, chemical biology, synthetic biology
30 8c Nikolaos Sgourakis, Ph.D Chemical and structural biology. Biomedical imaging, nanotechnology and supramolecular assemblies
55 6d Kim A. Sharp, Ph.D Theory and simulation of protein and nucleic acid structure and function
43 42 Yihui Shen, Ph.D Imaging and Systems Metabolism
57 68 Junwei Shi, Ph.D, Hepatocellular Carcinoma, epigenetic regulators, signal transduction
57 74 James Shorter, Ph.D, Regulation of neuropathogenic prions and amyloids by protein-remodeling factors, 19 molecular chaperones
84 Hongjun Song, Ph.D, Neurogenesis and Epigenetic/Epitranscriptomic 25 Mechanisms in the Nervous System
52 6a Yuanquan Song, Ph.D, Studying the formation, maintenance and function of neural circuits
57 37 Adam J. Stevens, Ph.D, Cancer Biology
1 1 29 1 3e 57 Bin Tian, Ph.D RNA processing and metabolism in cancer and immunity.
32 62 Cornelius Taabazuing, Ph.D Innate immunity. Molecular mechanisms of cell death.
99 Aaron Timperman, Ph.D, Microfluidics, Nanofluidics, Proteomics, Lab on a chip
8a Blanton Tolbert, Ph.D Molecular mechanisms of gene expression in RNA viruses, 27 transcriptional control of viruses
9b Dirk Trauner, Ph.D Chemical Biology, Optigenetic Control
1 37 6d Andrew Tsourkas, Ph.D Molecular imaging, drug delivery, nanotechnology, and biotherapeutics
7c Andrey Tvardovskiy, Ph.D Chromatin, Proteomics, Aging
1 29 1 54 7a Gregory D. Van Duyne, Ph.D, Structural biology; protein-protein interactions; x-ray crystallography
1 1 29 4f Liling Wan, Ph.D 56 , Chromatin and its regulatory network, cancer biology and epigenetics.
85 P. Jeremy Wang, MD, Ph.D, 6d Epigenetics in reproduction, spermatogonial stem cell self-renewal, silencing of transposable elements.
1 55 74 Felix W. Wehrli, Ph.D, MRI of biomaterials microstructure, mathematical modeling, image processing
56 76 Aalim Weljie, Ph.D, Circadian, sleep, environmental and cancer metabolism via metabolomics profiling
51 53 Kathryn E. Wellen, Ph.D, Cancer cell metabolism, nutrient sensing
57 5b Elizabeth Railey White, MD, PhD, Molecular mechanism of anesthesia action
51 7a Walter Witschey, Ph.D. Study of 44 cardiovascular disease using imaging and computational biology.
1 29 29 1 54 7c Xiaolu Yang, Ph.D, Molecular mechanisms of apoptosis and how they may relate to cancer and other diseases.
1c 1 4d 68 Kenneth S. Zaret, Ph.D, Investigating transcription factor interactions with chromatin
71 Lijun Zhou, Ph.D, 5c Nucleic Acid Chemistry, Non-Natural Nucleic Acids, Structural Biology, Artificial Cells
56 72 Zhaolan (Joe) Zhou, Ph.D, Epigenetic control of genome function in brain development and disease
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1d 6b